Description

amitriptyline for pain

amitriptyline for pain is a tricyclic antidepressant primarily used to treat major depressive disorder, and a variety of pain syndromes such as neuropathic pain, fibromyalgia, migraine and tension headaches.

Uses

What is amitriptyline used for?

Amitriptyline is commonly used to treat depression.

Amitriptyline may also be used for other conditions as determined by your healthcare provider.

How does amitriptyline work (mechanism of action)?

Amitriptyline is an antidepressant that belongs to a group of medicines called tricyclic antidepressants (TCAs). It works by increasing the amount of natural chemicals called norepinephrine and serotonin in the brain.

How is amitriptyline supplied (dosage forms)?

Amitriptyline is available in the following dosage forms that are taken by mouth.

10 mg oral tablets
25 mg oral tablets
50 mg oral tablets
75 mg oral tablets
100 mg oral tablets
150 mg oral tablets

How should I store amitriptyline?

Amitriptyline should be stored at room temperature, between 68 F to 77 F (20 C to 25 C). It can be exposed to temperatures between 59 F to 86 F (15 C to 30 C) for shorter periods of time, such as when transporting it. Store in a cool, dry place, in a tightly closed container. Protect from light.

Side Effects

What are the most common side effects of amitriptyline?

The most common side effects of amitriptyline are listed below. Tell your healthcare provider if you have any of these side effects that bother you.

Constipation
Inability to empty your bladder
Dry mouth
Drowsiness
Dizziness
Confusion
Blurred vision
Nausea and vomiting

What are the serious side effects of amitriptyline?

While less common, the most serious side effects of amitriptyline are described below, along with what to do if they happen.

Severe Allergic Reactions. Amitriptyline may cause allergic reactions, which can be serious. Stop taking amitriptyline and get help right away if you have any of the following symptoms of a serious allergic reaction.

Breathing problems or wheezing
Racing heart
Fever or general ill feeling
Swollen lymph nodes
Swelling of the face, lips, mouth, tongue, or throat
Trouble swallowing or throat tightness
Itching, skin rash, or pale red bumps on the skin called hives
Nausea or vomiting
Dizziness, feeling lightheaded, or fainting
Stomach cramps
Joint pain

Suicidal Thoughts or Actions. Amitriptyline or other antidepressants may increase the risk of suicidal thoughts or actions in a small number of children, teenagers, or young adults in the first few months of taking the medicine or when the dose is changed. Depression or other serious mental health conditions are the most important causes of suicidal thoughts or actions. If you or your child is about to harm themselves, call 911 or call or text 988, the Suicide & Crisis Lifeline. Call your healthcare provider right away if you have any of the following symptoms.